Scientific Publications and Patents

 

Zhang J., Osslund T. D., Plant M. H., Clogston C. L., Nybo R.E., Xiong F., Delaney J. M., Jordan S. R. (2005) Crystal Structure of Murine 11b-Hydroxysteroid Dehydrogenase 1:  An Important Therapeutic Target for Diabetes.  Biochemistry 44:6948-6957.

 

Jiang, X., Gurel, O., Mendiaz, E. A., Stearns, G., Clogston, C. L., Syed, R., Osslund, T. D., Langley, K. E., and Hendrickson, W. A. (2000) Structure of the active core of human stem cell factor and analysis of its binding to the Kit receptor.  EMBO J. 19:3192-3203.

 

Goruppi S.,  Yamane H.,  Marcandalli P., Garcia A., Clogston C., Gostissa M.,  Varnum B.,  and Schneider C. (1997) The product of a gas6 splice variant allows the release of the domain responsible for Axl tyrosine kinase receptor activation.   FEBS-Lett. 415:59-63.

 

Lavin AE, Merewether LA, Clogston CL, and Rohde MF.  (1997) Comparison of the high sensitivity and standard versions of Applied Biosystems Procise 494 N-terminal protein sequencers using various protein supports.  In Techniques in Protein Chemistry VIII, Daniel Marshak, ed., Academic Press, San Diego, CA.

 

Rohde MF, Clogston CL, Merewether LA, Derby PL, and Nugent KD. (1995) Protein sequence analysis using microbore PTH separations.  In Techniques in Protein Chemistry VI,  John W. Crabb, ed., Academic Press, San Diego, CA.

 

Merewether LA, Clogston CL, and Lu HS. (1995) Peptide mapping at the 1 ug level:  in-gel vs. PVDF digestion techniques.  In Techniques in Protein Chemistry VI,  John W. Crabb, ed., Academic Press, San Diego, CA.

 

Clogston CL, Derby PL, Toso R, Skrine JD, Parker V, Zhang M, Fox GM, Bartley TD, and Lu HS.  (1995) Carbohydrate structure characterization of two soluble forms of a ligand for the ECK receptor tyrosine kinase.  In Techniques in Protein Chemistry VI,  John W. Crabb, ed., Academic Press, San Diego, CA.

 

Hunt P,  Li L, Nichol JL, Hokom MM, Bogenberger JM, Swift SE, Skrine JD, Homkohl AC, Lu HS, Clogston CL, Merewether LA, Johnson MJ, Parker V, Garcia A, Farese A, Hsu R-Y, Stead R, Bosselman RA, and Bartley TD. (1995) Purification and biological characterization of plasma-derived megakaryocyte growth and development factor (MGDF).  Blood 86:540-547.

 

Varnum B, Young C, Elliott G, Garcia A, Bartley T, Fridell Y-W, Hunt RW, Trail G, Clogston C, Toso RJ, Yanagihara D, Bennett L, Sylber M, Merewether LA, Tseng A, Escobar E, Liu E, and Yamane HK. (1995) AXL receptor tyrosine kinase stimulated by the vitamin-K-dependent protein encoded by growth-arrest-specific gene-6.  Nature 373:623-626.

 

Wypych J, Bennett LG, Schwartz MG, Clogston CL, Lu HS, Broudy VC, Bartley TD, Parker VP, and Langley KE  (1995) Soluble c-kit receptor in human serum.  Blood 85:66-73.

 

Bartley TD, Bogenberger J, Hunt P, Li Y-S, Lu HS, Martin F, Chang M-S, Samal B, Nichol JL,  Swift S, Johnson MJ, Hsu R-Y, Parker VP, Suggs S, Skrine JD, Merewether LA, Clogston C, Hsu E, Hokom MM, Hornkohl A, Choi E, Pangelinan M, Sun Y, Mar V, McNinch J, Simonet L, Jacobson R, Xie C, Shutter J, Chute H, Basu R, Selander L, Trollinger D, Sieu L, Padilla D, Trail G, Elliott G, Izumi R, Covey T, Crouse J, Garcia A, Xu W, Del Castillo J, Biron J, Cole S, Hu M C-T, Pacifici R, Ponting I, Saris C, Wen D, Yung YP, Lin H, and Bosselman RA  (1994) Identification and Cloning of a Megakaryocyte Growth and Development Factor (MGDF) Which is a Ligand for MPL.  Cell 77:1117-1124.

 

Langley KE, Mendiaz EA, Liu N, Narhi LO, Zeni L, Parseghian CM, Clogston CL, Leslie I, Pope JA, Lu HS, Zsebo KM, and Boone TC (1994) Properties of Variant Forms of Human Stem Cell Factor Recombinantly Expressed in Escherichia coli.  Arch. Biochem. Biophys. 311:55-61.

 

Derby PL, Wypych J, Rush RR, Clogston CL, and Rohde MF  (1994) Site-specific glycosylation of recombinant stem cell factor.  In Techniques in Protein Chemistry V, John W. Crabb, ed.,  Academic Press, San Diego, CA.

 

Jones MD, Merewether LM, Clogston CL, and Lu HS  (1994) Peptide map analysis of recombinant human granulocyte colony stimulating factor: elimination of methionine modification and nonspecific cleavages.  Anal. Biochem. 216:135-146.

 

Lu HS, Fausset PR, Sotos LS, Clogston CL, Rohde MF, Stoney KS, and  Herman AC (1993)  Isolation and characterization of three recombinant human granulocyte colony stimulating factor His->Gln isoforms produced in Escherichia coli.  Protein Expr. and Purif. 4:465-472.

 

Clogston CL, Hu S, Boone TC, and Lu HS (1993).  Glycosidase digestion and electrophoretic analysis of recombinant human granulocyte colony  stimulating factor produced in Chinese hamster ovary cells.  J. Chrom. 637:55-62.

 

Lu HS, Clogston CL, Merewether LA, Narhi LO, and Boone TC  (1993)  The role of disulfide bonds in folding of recombinant human granulocyte colony  stimulating factor produced in Escherichia coli.  In Protein Folding in vitro and in vivo, C. Cleland and J. King, eds.  ACS Book Series.  ACS Publishing, Washington, D.C.

 

Lu HS, Clogston CL, Wypych J. Parker VP, Lee TD, Swiderek K, Baltera RF Jr., Patel AC, Chang DC, Brankow DW, Liu X-D, Ogden SG, Karkare SB, Hu SS, Zsebo KM, and Langley KE (1992) Post-translational processing of membrane-associated recombinant human stem cell factor expressed in Chinese hamster ovary cells.  Arch. Biochem. Biophysics 298:150-158.

 

Langley KE, Wypych J, Mendiaz EA, Clogston CL, Parker VA, Farrar DH, Brothers MO, Satygal VN, Leslie I, Birkett NC, Smith KA, Baltera RF Jr., Lyons DE, Hogan JM, Crandall C, Boone TC, Pope JA, Karkare SB, Zsebo KM, Sachdev RK, and Lu HS (1992). Purification and characterization of soluble forms of human and rat stem cell factor recombinantly expressed by E. coli and by Chinese hamster ovary cells.  Arch. Biochem. Biophysics 295:21-28.

 

Lu HS, Clogston CL, Narhi LO, Merewether LA, Pearl WR, and Boone TC (1992) Refolding and oxidation of recombinant human granulocyte colony-stimulating factor in E. coli.  J. Biol. Chem. 267:8770-8777.

 

Clogston CL, Hsu Y-R, Boone TC, and Lu HS (1992).  Detection and quantification of recombinant granulocyte colony-simulating factor charged isoforms: comparative analyses by cation exchange, high-performance liquid chromatography, isoelectric focusing gel electrophoresis, and peptide mapping.  Analytical Biochemistry 202:375-383.

 

Arakawa TA, Yphantis DA, Lary JW, Narhi LO, Lu HS, Prestrelski SJ, Clogston CL, Zsebo KM, Mendiaz EA, Wypych J, and Langley KE (1991) Glycosylated and unglycosylated human recombinant-derived stem cell factors are dimeric and have extensive regular secondary structure.  J. Biol. Chem. 266:18942-18948.

 

Lu H., Clogston C, Wypych J, Fausset PR, Lauren SL, Mendiaz EA, Zsebo K and Langley KE (1991) Amino acid sequence and post-translational modification of stem cell factor isolated from buffalo rat liver cell condition medium. J. Biol. Chem. 266:8102-8107.

 

Clogston CL, Boone TC and Lu HS (1989).  Human interleukin-6 (B cell growth factor II) has disulfide structures similar to granulocyte colony stimulating factor. Arch. Biochem. Biophys 272:144-151.

 

Patents Held

 

US2004024738 -- “Crystalline Tumor Necrosis Factor Receptor 2 Polypeptides”